Some evidence that Vit. B6 Improves Verbal IQ for Small Subgroup of children with PDDs

Besides being a beautifully simple-looking molecule, Pyridoxine Hydrochloride (a.k.a. vitamin B6) has long been known to be a highly beneficial nutritional supplement for humans, and works in symphony with vit. B2 and others to produce PLP (pyridoxal 5-phosphate). It’s long been known as an anti-oxidant and a preventer of many diseases, and is metabolised in the liver. Deficiencies in this vitamin have devastating effects on the human body.

More important with regards to ASDs and ADHD, PLP is a cofactor in the biosynthesis of five important neurotransmitters: serotonin, dopamine, epinephrine, norepinephrine, and GABA. Autism and ADHD have been linked to specific deficiencies in certain neurotransmitters. PLP helps convert the protein tryptophan into serotonin, and a study from 2006 showed that when used in combination with magnesium supplements, it reduced aggressiveness and improved attention for children with ADHD; however this study from 2005 proved inconclusive.

Although serotonin synthesis does not affect all symptoms of autism and ADHD, it’s definitely an important factor. Dopamine has also proven to be key.

The group of B vitamins is vital to the development of all children, and if you or your child are not already taking a B vitamin supplement every day, you should seriously consider it as an investment in preventative healthcare. 

Toxicities have occurred, therefore your own research and good judgement are required.

I have been taking a full spectrum, high strength B vitamin supplement since I was in my late teens. Although I cannot ascribe pyridoxine to my extreme sociability, I might be the world’s most social aspie.

The 2002 study referenced in the headerThe report of this study starts on the bottom right of the first page.

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